MersV1, Main, Exploration, bibRecord, 002E82

Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).

Identifieur interne : 002E82 ( Main/Exploration ); précédent : 002E81; suivant : 002E83

Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).

Auteurs : Justina Clarinda Wolters [Allemagne] ; Rupert Abele ; Robert Tampé

Source :

The Journal of biological chemistry [ 0021-9258 ] ; 2005.

RBID : pubmed:15863492

Descripteurs français

KwdFr :
- Adénosine triphosphate (métabolisme), Amorces ADN, Cinétique, Dimérisation, Humains, Peptides (métabolisme), Séquence nucléotidique, Transport de protéines, Transporteurs ABC (), Transporteurs ABC (métabolisme).
MESH :
- métabolisme : Adénosine triphosphate, Peptides, Transporteurs ABC.
- Amorces ADN, Cinétique, Dimérisation, Humains, Séquence nucléotidique, Transport de protéines, Transporteurs ABC.

English descriptors

KwdEn :
- ATP-Binding Cassette Transporters (chemistry), ATP-Binding Cassette Transporters (metabolism), Adenosine Triphosphate (metabolism), Base Sequence, DNA Primers, Dimerization, Humans, Kinetics, Peptides (metabolism), Protein Transport.
MESH :
- chemical , chemistry : ATP-Binding Cassette Transporters.
- chemical , metabolism : ATP-Binding Cassette Transporters, Adenosine Triphosphate, Peptides.
- Base Sequence, DNA Primers, Dimerization, Humans, Kinetics, Protein Transport.

Abstract

The transporter associated with antigen processing (TAP)-like (TAPL, ABCB9) belongs to the ATP-binding cassette transporter family, which translocates a vast variety of solutes across membranes. The function of this half-size transporter has not yet been determined. Here, we show that TAPL forms a homodimeric complex, which translocates peptides across the membrane. Peptide transport strictly requires ATP hydrolysis. The transport follows Michaelis-Menten kinetics with low affinity and high capacity. Different nucleotides bind and energize the transport with a slight predilection for purine bases. The peptide specificity is very broad, ranging from 6-mer up to at least 59-mer peptides with a preference for 23-mers. Peptides are recognized via their backbone, including the free N and C termini as well as side chain interactions. Although related to TAP, TAPL is unique as far as its interaction partners, transport properties, and substrate specificities are concerned, thus excluding that TAPL is part of the peptide-loading complex in the classic route of antigen processing via major histocompatibility complex class I molecules.

DOI: 10.1074/jbc.M503231200
PubMed: 15863492

Affiliations:

Le document en format XML

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<term>Base Sequence</term>
<term>DNA Primers</term>
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<term>Humains</term>
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<front><div type="abstract" xml:lang="en">The transporter associated with antigen processing (TAP)-like (TAPL, ABCB9) belongs to the ATP-binding cassette transporter family, which translocates a vast variety of solutes across membranes. The function of this half-size transporter has not yet been determined. Here, we show that TAPL forms a homodimeric complex, which translocates peptides across the membrane. Peptide transport strictly requires ATP hydrolysis. The transport follows Michaelis-Menten kinetics with low affinity and high capacity. Different nucleotides bind and energize the transport with a slight predilection for purine bases. The peptide specificity is very broad, ranging from 6-mer up to at least 59-mer peptides with a preference for 23-mers. Peptides are recognized via their backbone, including the free N and C termini as well as side chain interactions. Although related to TAP, TAPL is unique as far as its interaction partners, transport properties, and substrate specificities are concerned, thus excluding that TAPL is part of the peptide-loading complex in the classic route of antigen processing via major histocompatibility complex class I molecules.</div>
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Serveur d'exploration MERS

Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).

Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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